產地優勢 Advantages of origi

環境優勢 Environmental climate

廣西仙草堂制藥有限責任公司位于廣西壯族自治區北部的融安縣，地處中亞熱帶 季風區，有光照時間長、氣候溫暖濕潤、雨水充沛、冬短夏長的特點，地形地貌 多為中低山陡坡地貌、低山緩坡地貌、巖溶峰叢地貌、沉積平原地貌等幾種類型。

  Guangxi XianCaoTang Pharmaceutical Co., Ltd. is located in Rong'an County, where is in the northern part of Guangxi Zhuang Autonomous Region. This county is located in the central subtropical monsoon area, with long hours of light, warm and humid climate, abundant rainfall, short winters and long summers, and several types of topography and landforms, such as steep slope landforms in low mountains, gentle slope landforms in low mountains, karst crest landforms and sedimentary plain landforms.

 青蒿的生長特別喜溫暖、陽光，開闊、且排水良好的濕潤環境，微偏酸性的黃壤、 沖積土和紫色土；但青蒿忌水浸，且不耐蔭蔽。

 The growth of Artemisia is particularly fond of warm, sunny, open and well-drained moist environments, slightly acidic yellow soil, alluvial soil and purple soil. However, Artemisia should not be soaked in water and cannot tolerate shade.

  種源優勢 Origin of the species    

小知識：中藥里的“青蒿”指的是黃花蒿，青蒿素是從黃花蒿里面提取的；植物 學中的“青蒿”才是青蒿。 

廣西仙草堂制藥在決定開始青蒿項目之前，特別去了解青蒿這一植物，并尋遍全 國，看遍無數地方的青蒿，最后發現廣西融安縣內野生青蒿里的青蒿素含量較別 的地方要高很多。經許多科學家研究證實生長在熱量充足，降水豐沛地方的青蒿 中所含青蒿素含量比其他地方高很多。

       Trivia: The term "Artemisia" in Chinese medicine refers to Artemisia annua, from which Artemisinin is extracted; the term "Artemisia" in botany is Artemisia caruifolia.

   Before deciding to start the Artemisia project, Guangxi Xiancaotang Pharmaceutical Co., Ltd made a special effort to learn more about the plant and searched the country to see artemisia in countless places, and finally found that the Artemisinin content in wild artemisia in Guangxi Rong'an County is much higher than other places. Many scientists have researched and confirmed that Artemisinin is much higher in artemisia in places with plenty of heat and precipitation.

科研優勢與成果 Research advantages and achievements

  廣州中醫藥大學李國橋教授團隊合作

在青蒿種源方面，廣西仙草堂制藥投入大量的人力與資金進行良種研究，2009 年 11 月，廣西仙草堂制藥與廣州中醫藥大學李國橋教授團隊合作開展青蒿優質 種源的研究和生產，通過企業與院校之間的合作共同開發高含量、高產量的青蒿 種源并進行產業化推廣應用。

   Guangzhou University of Traditional Chinese Medicine Professor Li Guoqiao team cooperation

In November 2009, Guangxi Xiancaotang Pharmaceutical Co., Ltd cooperated with Professor Li Guoqiao's team from Guangzhou University of Chinese Medicine to carry out research and production of high quality seeds of Artemisia annua, through the cooperation between enterprises and institutions to jointly develop high content and high yield of Artemisia annua seeds and to promote the application of industrialization.

   李國橋 Li Guoqiao

國際知名青蒿素類抗瘧疾藥物研究專家 “以身試瘧疾病第一人”廣州中醫藥大學首席教授，博士生導師，青蒿研究中心主任，廣東省名中醫，國 際知名瘧疾防治專家 　

     Internationally renowned expert in the research of Artemisinin-based anti-malarial drugs  "The first person to test malaria disease with his own body"  Chief Professor of Guangzhou University of Chinese Medicine, Doctoral Supervisor, Director of Artemisinin Research Centre, Guangdong Famous Chinese Medicine Doctor, internationally renowned expert in malaria prevention and treatment.

     中國中醫藥科學院合作    Cooperation with the China Academy of Chinese Medical Sciences

2017 年 9 月，廣西仙草堂制藥與中國中醫科學院中藥研究所合作建立全球第一 個青蒿、靈芝良種培育及生態種植基地，并在青蒿和靈芝的種質資源、良種選育、 生態種植、規范化采收、病蟲害防治等品種培育和生態種植方面開展合作研究。 （注：中國中醫科學院中藥研究所始建于 1955 年，是我國成立最早的一所國家 級研究中藥的專門機構。自 1983 年起被確認為世界衛生組織傳統醫學合作中 心。）

In September 2017, Guangxi XianCaoTang Pharmaceutical Co., Ltd. and the Institute of Traditional Chinese Medicine of the Chinese Academy of Traditional Chinese Medicine cooperated to establish the world's first base for cultivating and ecological planting of Artemisia annua and Ganoderma lucidum, and to conduct cooperative research in the cultivation and ecological planting of Artemisia annua and Ganoderma lucidum in terms of germplasm resources, selection and breeding of good seeds, ecological planting, standardized harvesting, pest control and other varieties. (Note: The Institute of Traditional Chinese Medicine of the Chinese Academy of Traditional Chinese Medicine was established in 1955 and is one of the earliest national specialized institutions for the study of traditional Chinese medicine in China. It has been recognized as a WHO Collaborating Centre for Traditional Medicine since 1983.)

  黃花蒿（青蒿）規范種植制定單位 The formulating unit for the standardized cultivation of Artemisia annua

由融安縣人民政府提出,由廣西仙草堂制藥有限責任公司等單位共同起草的《青 蒿素生產技術規程》（DB45/T 1639-2017）廣西地方標準，于 2019 年 6 月 27 日 在南寧，順利通過由廣西市場監督管理局組織的專家組審定。 該標準是一項填補國內青蒿素行業空白的新標準，結束了我國沒有青蒿素生產技 術標準的歷史；該標準將用于規范青蒿素生產，提高產品質量，著力提升品牌形 象與核心競爭力，進一步提升生產效益，有力助推青蒿素產業做大做強；該標準 將進一步推進廣西仙草堂制藥有限責任公司與中國中醫科學院中藥研究所（屠呦 呦團隊）的合作協議，全面開展項目合作研究。

      The "Technical Regulations for Artemisinin Production" (DB45/T 1639-2017) Guangxi local standard proposed by the Rong'an County People's Government and jointly drafted by Guangxi Xiancaotang Pharmaceutical Co., Ltd. and other units, was held in Nanning on June 27, 2019, It successfully passed the examination and approval of the expert group organized by Guangxi Market Supervision and Administration Bureau. 

      This is a new standard to fill the blank of domestic Artemisinin industry, ending the history of no technical standard for Artemisinin production in China; the standard will be used to standardize Artemisinin production, improve product quality, make efforts to enhance brand image and core competitiveness, further improve production efficiency, and strongly promote the Artemisinin industry to become bigger and stronger; the standard will further promote the cooperation between Guangxi XianCaoTang Pharmaceutical Co. Ltd. and the Institute of Traditional Chinese Medicine of the Chinese Academy of Traditional Medicine (Tu Youyou's team) to fully carry out cooperative research on the project.

   專利發明與成果  Patent inventions and achievements

經過多年的探索與不斷的努力，廣西仙草堂制藥自 2005 年開始實施青蒿項目以 來，實施完成國家科技項目 2 個，創新《青蒿素綠色提取工藝》發明專利。

After years of exploration and continuous efforts, Guangxi Xiancaotang Pharmaceutical Co., Ltd has implemented and completed 2 national science and technology projects since the start of the Artemisia project in 2005, and innovated the "Green Extraction Process of Artemisinin" invention patent.

小知識：《青蒿素綠色提取工藝》

技術領域 本發明涉及藥物生產領域，是一種青蒿素的提取工藝。

背景技術

青蒿素（Artemisinin）是從藥用植物黃花蒿（Artemisia annua Linn）中提取的青蒿 素類藥物，為含有過氧化基團的倍半花內酯化合物，是我國唯一得到國際認 可按西藥研制的中草藥提取物，是世界衛生組織（WHO）明確規定取代奎寧 的抗瘧疾原料藥。我國的青蒿素產銷量占全球產銷量的 90%以上，中國的提 取技術也就代表著世界水平。

目前國內黃花蒿中提取青蒿素的工藝主要是傳統的有機溶媒提取分離法，即 采用有機溶劑如乙醇、丙酮、汽油等對黃花蒿進行提取得到提取液浸膏后， 再經過大孔樹脂或硅膠柱分離結晶得到青蒿素純品，該技術工藝簡單成熟， 國內絕大多數青蒿素生產企業都沿用這種經典的提取方法。其主要的缺點是 提取時間長，提取率低，溶媒、能源消耗大，環境污染大等。由于該法的大 生產應用始于 2004 年，至今不到十年時間，因而改進的空間很大。

綠色提取法也稱超臨界二氧化碳萃取法，該法廣泛地用于香料的提取，具有 環境 良好、操作安全、不存在有害物殘留、產品品質高且能保持固有氣味 等特點。進入 90 年代后，超臨界二氧化碳萃取技術開始運用于從藥用植物 中提取藥用有效 成分等，據報導我國在青蒿素的超臨界流體萃取也有研究， 但終因此法存在設備投入大，生產能力低、運行成本高，沒有市場競爭力的 缺點，在國內外至今尚沒有一家企業進行過大規模的工業生產。

廣西仙草堂制藥采用的青蒿素綠色提取工藝具有以下有益效果： 

1、可有效降低生產成本、提高經濟效益 

2、解決青蒿素在提取過程中受熱分解而影響收率的問題 

3、節能、降耗、清潔、大幅減少廢棄物排放

      Little knowledge: The Artemisinin Green Extraction Process

      Technical field

  The present invention relates to the field of pharmaceutical production and is a process for the extraction of Artemisinin.

     Background technology

Artemisinin is an Artemisinin-like drug extracted from the medicinal plant Artemisia annua Linn. It is a sesquiterpene lactone compound containing peroxide groups and is the only Chinese herbal extract in China that has been internationally recognized as a Western medicine, and is an anti-malarial API explicitly prescribed by the World Health Organization (WHO) to replace quinine. China's Artemisinin production and sales account for more than 90% of global production and sales, so China's extraction technology also represents the world level.

At present, the main method of extracting Artemisinin from Artemisia annua in China is the traditional organic solvent extraction and separation method, i.e. using organic solvents such as ethanol, acetone and gasoline to extract Artemisia annua to obtain the extract infusion, and then separating and crystallizing it by macroporous resin or silica gel column to obtain the pure product of Artemisinin. The main drawbacks are the long extraction time, low extraction rate, high solvent and energy consumption and environmental pollution. Since the application of this method in large-scale production started in 2004, less than ten years ago, there is a lot of room for improvement.

The green extraction method, also known as supercritical carbon dioxide extraction method, is widely used in the extraction of spices, and has the characteristics of environmental friendliness, safe operation, no residue of harmful substances, high product quality and can maintain inherent odor. After the 1990s, supercritical carbon dioxide extraction technology began to be applied to the extraction of medicinal active ingredients from medicinal plants, etc. According to reports, China has also conducted research on supercritical fluid extraction of Artemisinin, but in the end, this method has the disadvantages of large investment in equipment, low production capacity, high operating costs and no market competitiveness.

The Artemisinin green extraction process adopted by Guangxi Xiancaotang Pharmaceutical Co., Ltd has the following beneficial effects.

1、It can effectively reduce the production cost and improve the economic efficiency

2、Solve the problem of thermal decomposition of Artemisinin in the extraction process and affect the yield

3、Energy saving, consumption reduction, cleanliness and significant reduction of waste emission

基地優勢 Advantages of the base

    青蒿種植合作社  Artemisia planting cooperative

2006 年起，廣西仙草堂制藥以“青蒿種子”合作的形式和種植戶牽頭人共同建 立青蒿種植合作社，開展青蒿的種植。經過多年的用心經營，目前共建立了 7個青蒿種植合作社，由廣西仙草堂制藥免費提供青蒿種和青蒿種植技術指導培 訓，并與農戶簽訂原料保底價回收青蒿。 青蒿一般在 1 月中旬播種，待幼苗長成后經過大約 120 天的成長后收割，將葉子 曬干送回工廠加工提取青蒿素。

  Since 2006, Guangxi Xiancaotang Pharmaceutical Co., Ltd has established Artemisia planting cooperatives in the form of "Artemisia seeds" cooperation with the leaders of farmers to carry out the cultivation of Artemisia. After years of dedicated management, a total of 7 Artemisia planting cooperatives have been established, with Guangxi Xiancaotang Pharmaceutical Co., Ltd providing free artemisia seeds and technical guidance and training on artemisia planting, and signing a contract with farmers to recover artemisia at a guaranteed price for raw materials.

Artemisia annua is usually sown in mid-January, and harvested after about 120 days of growth when the seedlings are grown, and the leaves are dried and sent back to the factory for processing to extract Artemisinin.

全球最大種植基地  The world's largest planting base

自 2005 年廣西仙草堂制藥開展青蒿素項目以來，從 2006 年開始建立自己的種植 基地，經過十多年的持續努力與發展，到目前基地面積擴大至將近 4 萬畝，是目 前全球最大的青蒿種植基地。

Since 2005, when Guangxi Xiancaotang Pharmaceutical Co., Ltd started the Artemisinin project, it started to establish its own cultivation base from 2006. After more than ten years of continuous efforts and development, the base area has expanded to nearly 40,000 mu at present, which is currently the largest Artemisinin cultivation base in the world.

種植模式   Planting mode

　“公司+科研單位+合作社+農戶”"Company + scientific research unit + cooperative + farmers"

自 2009 年起，廣西仙草堂制藥開始“公司+科研單位+合作社+農戶”的產業化模 式，可以帶動鄉村發展，創造了更多的就業崗位，幫助農戶增加了收入。 “公司+科研單位+合作社+農戶”模式由公司免費提供種子，科研單位負責種子 的選育培優，公司通過合作社進行種植技術的指導與培訓；公司與農戶進行保底 價收購，在保障公司原料產量的同時，也實現為農戶帶去經濟效益的雙贏。

Since 2009, Guangxi Xiancaotang Pharmaceutical Co., Ltd began to "company + scientific research units + cooperatives + farmers" industrialization model, can drive the development of the countryside, creating more jobs, to help farmers increase their income.

The "Company + Scientific Research Unit + Cooperative + Farmers" model consists of the company providing free seeds, the scientific research unit is responsible for the selection and cultivation of seeds, the company provides guidance and training on planting techniques through the cooperative; the company and the farmers make guaranteed price purchases, which guarantees the production of the company's raw materials while also achieving a win-win situation by bringing economic benefits to the farmers.

融安縣在滇桂黔石漠化片區上，有相當多的荒山坡地不適宜種植農作物，青蒿素產業有效推進廣西石漠化片區土地利用，為農民脫貧致富解決了一大困難，助力 精準脫貧。青蒿產業惠及農戶 1 萬余戶，戶均增收 4500 元，其中借助青蒿素產 業脫貧 4700 余戶、1.8 萬余人,青蒿成為貧困山區的“致富草”、成為山區人民 心中的“仙草”。

The Artemisinin industry has effectively promoted the use of land in the stone desertification area of Guangxi, solving a major difficulty for farmers to get rid of poverty and helping them to get rid of poverty precisely. The Artemisinin industry has benefited more than 10,000 households, with an average household income of 4,500 yuan, of which more than 4,700 households and 18,000 people have been lifted out of poverty by the Artemisinin industry.

榮譽資質